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10.1186/s13287-023-03524-z 61 HosseiniS.ShokriF.Ansari PourS.Jeddi-TehraniM.NikooS.YousefiM.et al (2016)

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developed a novel hypoxia-activated combination nanomedicine that targets hypoxic tumors through hypoxia-sensitive block copolymers and photothermal/photodynamic therapy (PTT/PDT), efficiently delivering drugs and achieving synergistic anticancer effects of chemotherapy and PDT/PTT, completely eliminating advanced breast cancer, including hypoxic and metastatic tumors, stimulating a systemic antitumor immune response, and significantly improving survival rates, showing important clinical application potential [500]