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Furthermore, analysis of different gene expression patterns showed that H 2 O 2 altered cellcell connections more markedly in 3D cultures by downregulating polarity-related signaling pathways in HUVECs through a reduced expression of claudin 1 gene and VE-cadherin, compromising the barrier function

The relative importance of the three enzymes appears to be related to the H 2 O 2 levels in the RBC [59]

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