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If an additive or a synergistic effect of multiple Nrf2 activators provides significant Nrf2 activation, it may explain why diets rich in plant foods have been shown epidemiologically to significantly benefit human health [78]

Caffeine is also a diuretic, meaning it makes you urinate more frequently, which can contribute to dehydration right when you need to be hydrated the most

Large, well-powered RCTs are needed to confirm their efficacy and safety

Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone x receptor to activate the CYP3A23 hormone response element

From angiotensin IV binding site to AT4 receptor