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Previous studies indicated that the MCP-induced Gal-3 inhibition exhibited anti-inflammatory effects in animal models analyzing erectile dysfunction ( Unresolved inflammation and abnormal tissue repair can result in tissue fibrosis ( Gal-3 is mandatory for TGF--induced myofibroblast activation and extracellular matrix production ( Hepatic and pulmonary fibrosis induced by MTX were additionally confirmed by Massons trichrome staining which showed the proliferation of fibrous tissue, as previously reported ( Several studies reported that the induction of apoptosis may mediate MTX-induced liver ( Galectin-3 has a tumor-promoting effect in different tumors (Yan and Katz, 2010), ovarian ( In conclusion, this study demonstrates that MCP protects against MTX-caused hepatic and pulmonary toxicity through anti-inflammatory, antiapoptotic, antifibrotic, and antioxidant properties
Schag K, Schmidt SM, Mller MR, Weinschenk T, Appel S, Weck MM, et al
Journal of Alternative and Complementary Medicine, 17(9), 827-833
Bailey SJ, Blackwell JR, Lord T, Vanhatalo A, Winyard PG, Jones AM