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To counteract mitochondrial ROS and prevent aging, high glucose increases mitophagy in human aortic ECs (61)

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They developed a fusion protein of the ROS scavenger glutathione peroxidase (GPX1) (that can neutralize superoxide and peroxide) and TRF1 (to localize GPX1 to telomeres)

Moreover, when arginine 447, a residue conserved in all EAATs, of EAAC1 is replaced by cysteine, glutamate transport is abolished but cysteine transport remains intact [106]

However, the most important caveat applies here: human pharmacokinetic data confirming systemic oral bioavailability does not exist in the peer-reviewed literature as of 2025