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Although treatment with each of the three compounds alone was also effective, the combination of chlorogenic acid (CA), neochlorogenic acid (NCA), and cryptochlorogenic acid (CCA) demonstrated the greatest effect on HCECs in the scratch wound-healing assay

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Modulators of the p53 pathway, such as FOXO4-DRI and MDM2 inhibitors, selectively eliminate senescent cells but face challenges in clinical translation