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The 20th century marked rolling papers transition from tobacco-focused products to cannabis-friendly alternatives

Once in the stomach, food is prevented from refluxing (moving back into the esophagus), by a special area of circular muscle located at the junction of the esophagus and stomach, called the lower esophageal sphincter (LES)

On average, one milliliter of e-liquid produces 200 puffs

Adaptive trials can make the most efficient use of resources [18] by potentially allowing conclusions to be reached more quickly, and requiring smaller sample sizes on average than traditional trial designs, or avoiding unnecessary use of resources conducting underpowered trials

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