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10.1046/j.1528-1157.44.s10.5.x Epilepsia 45 PelzerN.LouterM

However, from a translational standpoint, targeting cytoskeletalmitochondrial interactions is challenging because systemic microtubule modulators or actin-targeting drugs have narrow therapeutic windows and substantial toxicity, particularly for proliferating cells such as bone marrow progenitors and intestinal epithelium

In addition to functioning as a purification tag, GST acts as a chaperone for the attached protein, promoting its correct folding, as well as preventing it from becoming aggregated in inclusion bodies when expressed in bacteria