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The first domain is responsible for GSH binding, with the presence of a specific binding task which is termed G-site

Journal of Neuroscience 16, 2553-2562CrossRefGoogle ScholarPubMed 92Drukarch, B., Schepens, E., Jongenelen, C.A

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Furthermore, a comprehensive review published in the Journal of Translational Medicine proposed a unifying model for ME/CFS and Long COVID, highlighting how viral infections (like SARS-CoV-2 or Epstein-Barr Virus) trigger a cascade of immune exhaustion, micro-clotting, and severe oxidative stress