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We observed that Nlrp3 / macrophages present an intrinsically protective redox state and this could be the reason why macrophages did not produce ROS after sUA+LPS stimulus

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However, in the normal physiological conditions follicular fluid NO seems to be synthesized from granulosa cells by endothelial NO synthase, since in isolated human follicular cells at least 90% of cells are granulosa cells even though macrophages and lymphocytes are present as well