tobacco and nicotine difference between Vapes VS. Cigarettes, Which One Is Safer? Synthetic Nicotine vs Tobacco-Derived Nicotine:

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Many smokers find that this feels more familiar to the way a cigarette satisfies over time rather than providing an immediate nicotine rush

I could see this making a good base for blending if that's your thing

Andrews J, Hampson S, Greenwald A, Gordon J, and Widdop C