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Soluble A oligomers inhibited EAAC1-mediated cysteine uptake and decreased intracellular GSH levels in vitro , even though mRNA expression of EAAC1 was reactively increased by treatment with soluble A oligomers [111]

Peptide stacking introduces additional storage considerations because different peptides in a stack may have different stability requirements

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Moreover, only 54% of patients in those economics have access to oral cysteamine therapy, and there is limited access to cysteamine eye drops, supportive therapies, and standard diagnostic and monitoring tools, all of which are essential for the prevention of disease progression and extended lifespan [159]

The rat MCL study showed progressive improvement at 14, 30, 45, and 90 days