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demonstrated that FK228, an HDAC inhibitor, induces histone hyperacetylation in synovial cells, leading to reduced levels of tumour necrosis factor (TNF-) and interleukin-1 (IL-1) and the inhibition of vascular endothelial growth factor production [34]

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10.1093/jxb/erad018 52 ItoT.KitaiwaT.NishizonoK.UmahashiM.MiyajiS.AgakeS.et al (2022)

Its phosphate group is readily donated to ADP, thereby boosting the ATP content of the muscle celln as they hydrolyse ATP for energy to derive muscle contraction

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