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The deposition of the powder and absorption of the drug from a powder formulation for nasal delivery depends on many factors, including the shape and size of powder particles, solubility, and flow characteristics [18]

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Future medicinal chemistry efforts may yield next-generation compounds with enhanced properties, including improved tissue selectivity, modified pharmacokinetics, or additional mechanistic activities that complement NNMT inhibition

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doi: 10.3978/j.issn.2072-1439.2012.09.01