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COMT degrades catechol estrogens so they can be cleared from the body and polymorphisms of the enzyme are associated with an increased risk of fibroids

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Nijs J, Malfliet A, Roose E, Lahousse A, Van Bogaert W, Johansson E, et al

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The mechanism by which neutralization of IL-10 enhanced monocyte recruitment to the liver was not fully uncovered from our studies, however, it may involve changes to the levels of the monocyte chemokine, Ccl2 or the fibrinolytic enzyme, uPA