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10.1007/s13346-018-00613-y [DOI] [PubMed] 15.Parry Strong A, Haeusler S, Weatherall M, Krebs J (2016) Sublingual vitamin B12 compared to intramuscular injection in patients with type 2 diabetes treated with metformin: a randomized trial

B12 is mostly found in animal-based diets

After that, discard and open a new vial

Antiepileptic medicines (Phenytoin, Phenobarbital): Long-term use of these medicines may affect vitamin B12 levels and reduce response to supplementation