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That is, a study testing an intervention for toddlers with ASD and average IQs should not use a sample of autistic school-aged children with an uncharacteristically high rate of intellectual disability

Nakao A

Deficiency can intensify over time

Initially focused on metabolism, research showed NNMT elevation with age/weight leads to fat accumulation, inefficiency, and NAD+ loss.[30][31] High NNMT correlates with insulin resistance and obesity in humans