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La extrapolacin de estas dosis al ser humano, utilizando los factores de conversin alomtricos estndar (factor de 6,2 para la rata), da dosis tericas del orden de 1,6 g/kg en humanos

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Epigenetic modifications, including hypomethylation of ER and aromatase promoters, further sustain this estrogen-driven phenotype, with endocrine-disrupting chemicals (EDCs) such as dioxins and phthalates potentially exacerbating these epigenetic alterations ( Progesterone resistance, characterized by impaired progesterone receptor (PR) signaling despite bioavailable progesterone, perpetuates ectopic lesion survival and contributes to infertility ( The interplay of estrogen dominance and progesterone resistance disrupts endometrial homeostasis, directly impacting fertility

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