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Conceptually, ageing reduces the functional capacity of all organs and systems, ultimately weakening the whole organism, reducing its adaptability, wearing out its defensive systems and bringing it to death through age-dependent diseases

Calabrese et al., 2021)

Many people who struggle with vitamin B12 deficiency often experience reduced energy levels, brain fog, and even mood disturbances

Finally, we systematically compiled and summarized the eligible studies to present a holistic overview of the current landscape of TCM and TM applications in HACE management (Tables 1, 2) (Figure 1)

The resulting small-molecule free lysate was then concentrated twice to a concentration of 36 mg ml 1 , during which we lost 10,000 cells were initially analysed using FACS