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He is said to have once offered his snuffbox to the head of some religious order, who declined to take a pinch of snuff, saying, Your Holiness, I do not have that vice, to which the pope replied, It is not a vice

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[26] Adolescents [edit] Hormonal imbalance (elevated ratio of estrogen to androgen) during early puberty, either due to decreased androgen production from the adrenals and/or increased conversion of androgens to estrogens, leads to transient gynecomastia in adolescent males

Eventually, Tadao acquiesced

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