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In fact, ROS-modulating therapies share certain similarities with existing treatments such as chemotherapy and immunotherapy, that is, pro-oxidative stress strategies to further kill tumor cells and other cells, which has been recognized as a promising approach to improve treatment outcomes for decades [564, 565]

Research indicates that RhoA can suppress the expression of several adhesion molecules such as ZO-1, Connexin 43 in ECs, thereby increasing vascular permeability (38)

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