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Kozakova M, Palombo C, Paterni M, Dekker J, Flyvbjerg A, Mitrakou A, Gastaldelli A, Ferrannini E

Int J Biol Macromol 249:125952

GSH depletion has long been considered to play a causal role in oxidative stress-related cellular dysfunction/cell death

To assess the general relevance of the investigated positions in the context of alternative arGSTs, we introduced three selected substitutions (A/V12M, C13S and N108H) into the two well-studied arGSTs Ph AN9 and Vv GST4

Glutathione has been shown to have a positive effect on the skin, neutralising the free radicals and enhancing the cell repair mechanism, and balancing the melanin production