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They could not determine whether obesity lowers B12 levels or if low B12 levels predispose someone to obesity

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The report was uncontrolled, unblinded, not randomized, had no comparator arm, used patient-reported outcomes rather than validated pain instruments, and did not publish dose, effect size, confidence intervals, p-values, or systematically collected adverse events limitations that severely constrain any clinical inference

Usar otra alternativa sin entender las implicaciones no es un ahorro sino un riesgo experimental real

doi: 10.1016/j.jsps.2022.11.008 20