It is also worth noting that a large cluster of long heparan polymers on the cell surface could be associated with multiple dimeric c-MET/HGF complexes and in principle induce the higher-order oligomerization of c-METs, and potentially lead to the formation of even larger biomolecular condensates on the cell membrane
To further validate Pgp as the potential target, tamoxifen was used to treat monoclonal antibody-Pgp in leukemia cell line K562, it was confirmed that tamoxifen competed with the antibody for the binding [37]
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Bone mineral density and lean mass gains were observed in aged rat models, consistent with expected GH/IGF-1 axis activity