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Concentration = Total peptide (mg) / Total water added (mL) For a 30 mg vial: Add 1 mL = 30 mg/mL (very concentrated) Add 2 mL = 15 mg/mL (concentrated) Add 3 mL = 10 mg/mL (standard, recommended) Add 4 mL = 7.5 mg/mL (dilute) Add 5 mL = 6 mg/mL (very dilute) Add 6 mL = 5 mg/mL (most dilute practical option) Each of these concentrations works

Sporadic injections offer only temporary perks

Transwell BBB models with iPSC-derived endothelial cells from AD patients with a PSEN-1 mutation have found distinct BBB properties, including responses to ultrasound, used to permit drug delivery (Oikari et al., 2020)

Reynolds JC, Lai RW, Woodhead JST, Joly JH, Mitchell CJ, Cameron-Smith D, Lu R, Cohen P, Graham NA, Benayoun BA, Merry TL, Lee C

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