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A small randomized study (9) with N=60 patients where melatonin was orally administrated (3mg/day) from day 3-5 until hCG administration (oocyte collection) showed: a higher number of total oocytes (11.5 vs 6.9) higher number of mature oocyte (9% vs 4.4%) a higher rate of embryos transferred (69.3% vs 44.8%) These results were confirmed in another independent trial (10)

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This state localized to an immune-infiltrated but functionally exhausted niche with checkpoint enrichment, including PD-L1, shaped by cytokine signaling networks

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