After injection, oocytes were arrested for 18 h in M2 medium containing 2.5 M milrinone (S2484, Selleck) to allow complete degradation of Pcbp1 mRNA
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For example, for tumors with high RRM2 expression, the model recommends combining with CDK4/6 inhibitors to block DNA repair (Seetharam et al., 2024), for patients with low hENT1 expression and drug resistance, albumin nanoparticles or HDAC inhibitors are preferred to restore drug uptake (Roca et al., 2022)
TB-500s appeal is the opposite: a clean, well-defined mechanism centred on a single, well-characterised protein family