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Pickart and Margolina's review provides the broader gene expression context for why these effects occur

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Low-dose protocols (0.250.5mg daily) are derived from studies where systemic copper peptide administration at 24 mcg/kg demonstrated follicle-stimulating activity without elevating serum copper above the normal range (70140 mcg/dL)

The vasodilation effect of BPC 157 was nitric oxide mediated because the addition of L-NAME or hemoglobin inhibited the vasodilation of aorta