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Evidence also indicated a direct association between phases of migraine attacks and calcitonin gene-related peptide (CGRP), mitochondrial disorders, monoaminergic pathway, magnesium deficiency, and higher serum levels of glutamate (13, 14)

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The response to linsitinib is inferior to the topoisomerase inhibitor topotecan, with median progression-free survival of 3.0 (95% CI 1.53.6) and 1.2 (95% CI 1.11.4) months for topotecan and linsitinib, respectively [159]