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2 Structure of SARS-CoV/SARS-CoV-2 Spike Protein and its Interactions with Human Cell-Surface Receptor ACE2 2.1 Coronavirus Structure Among the structural proteins of coronaviruses, at least four are encoded in all coronaviruses: the nucleocapsid (N) protein, the membrane (M) protein and the envelope (E) protein, which are involved in viral assembly, and the spike (S) protein, which is involved in viral entry into host cells (Fig