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Moreover, overproduction of ROS has an impact to enhance the cancer cell proliferation, migration, metastasis, invasiveness and poor prognosis through many cellular mechanisms like matrix degradation, cell-cell contact, cell remodelling, as well as regulation of gene expression [54]

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When the stress response activates (whether from psychological stress, physical trauma, sleep deprivation, or environmental triggers), it directly stimulates mast cells to degranulate, releasing histamine and other inflammatory mediators into surrounding tissue and the bloodstream