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FOXO4-DRI at 25 mM concentration selectively induced p53 nuclear exclusion and apoptosis in the senescent Leydig cells, confirmed by Annexin V-FITC/PI apoptosis assays and immunofluorescent staining of Ser15-phospho-p53 foci
T.KersemansV.MichotteY.et al (2005)
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It is indicated for: Promotion of fat metabolism and oxidation Preservation of lean muscle mass during weight management Support for energy expenditure and metabolic efficiency Assistance in cellular energy homeostasis and anti-aging metabolic pathways Contraindications & Warnings Do not use if you have: Known hypersensitivity to 5-Amino-1MQ or any excipient Severe uncontrolled hypertension or cardiac arrhythmias Active malignancy or history of hormone-dependent cancer Severe hepatic or renal impairment Age under 18 years Pregnancy or breastfeeding Warnings Use only under medical supervision
not for human or veterinary application References Banerjee R., Ragsdale S.W
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