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One common approach is to take 20-25 g of creatine monohydrate daily for 5-7 days and divided into 4-5 g servings per day this is known as creatine loading ( 11 , 12 )

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Tears of patients with dry eye show significantly increased osmolarity, with a mean value of 343 mOsm compared with 302 mOsm in healthy controls [162]

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It also modulates serotonin, dopamine, and norepinephrine in limbic circuits (Zozulia et al., Zh Nevrol Psikhiatr Im SS Korsakova 2008)