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We and others also demonstrated that hemin induces the expression of NRF2 in SCD erythroblasts and animal models and such effect is mitigated by administration of dimethyl fumarate (DMF) 23,24 , an FDA-approved drug for the treatment of multiple sclerosis

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LeTrilling et al , 2018) due to the inability to interfere with STAT2dependent IFN signalling as evident from the restored replication in STAT2deficient mice (LeTrilling et al , 2018)

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