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ROS production can occur at several intracellular sites but, for most cells, takes place in the mitochondria and the mitochondrial electron transport chain is the main cellular process of ROS generation in physiological circumstances (14)

In cisplatin and ischemiareperfusion models, vitamin D protects tubular cells by downregulating ferroptosis-related molecules, including acyl-CoA synthetase long-chain family member 4 (ACSL4) and prostaglandin-endoperoxide synthase 2 (PTGS2) ( Clinically, multiple cohort studies support a causal link between vitamin D deficiency and AKI risk

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Reversal of Cancer Multidrug Resistance (MDR) Mediated by ATP-Binding Cassette Transporter G2 (ABCG2) by AZ-628, a RAF Kinase Inhibitor

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