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Improving folate bioavailability through processing Because intestinal deconjugation of polyglutamates to monoglutamates is the rate-limiting step in intestinal folate absorption, an increase of folate monoglutamate portion in foods may improve the bioavailability of dietary folate 1,37,216

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Acute cholecystitis This is the most frequent complication of biliary sludge or gallstones (calcolous cholecystitis) occurring in up to 11% of gallstone patients over a median follow-up of 711 years [10]

PMC, 2020

Data are limited, the risk is theoretical and requires thorough investigation prior to administration in individuals attempting conception