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There were inhibited mRNA of inflammatory mediators (iNOS, IL-6, IFN and TNF-), increased expression of HSP 70 and 90, and antioxidant proteins, such as HO-1, NQO-1, glutathione reductase, glutathione peroxidase 2 and GST-pi [30]

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Some work investigates muscle regeneration, where NNMT inhibition appears to enhance stem cell activity and myoblast differentiation in aged models

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This is said to occur in a small percentage of peptide therapy patients and tends to be mild, as well as transient