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What is the scope of the problem

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"Reading backwards from the official numbers, the use of illegal tobacco in Australia has absolutely roared in the last handful of years," he said

Mechanistically, it appears plausible that exposure to tobacco smoke can skew immune responses by impairing Th1-type and augmenting Th2-dependent responses, mainly by altering the immune functions of a variety of immune cells and aggravating the allergic inflammation and sensitization [3,11,12,13,14,15,16,17,18,19]