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Similarly, RNAseq data analysis(28) of inflammatory pathways from lungs of female mice exposed to e-cigarette aerosol for 3 to 6 months showed upregulation of activation of DCs, defined by increased MAPK, NLRs, JAK/STAT, and TNF, suggesting that e-cigarette vapor may consistently be activating the MAPK pathway in particular, leading to alterations in cytokine production, endocytosis, and T-cell polarization(37)

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