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Mechanical factors including respiratory muscle activity [3] associated with pulmonary hyperinflation [46], temporal adaptation [79] and bronchial hyperresponsiveness [7], psychological factors [10] or emotional and cognitive factors [11] have been proposed to influence the perception of dyspnea

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[165] A 2013 study examined 33 countries and found that only 1% of the adult smokers exclusively used non-nicotine e-cigarettes

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