aeruginosa has been shown to upregulate mucin secretion through the activation of the EGFR pathway by inducing intracellular reactive oxygen species, triggering cytokine production (e.g., IL-1, IL-1, IL-6, IL-8, TNF-), and generating EGFR ligands such as TGF- in epithelial cells (Shao et al., 2003
Dioun Allergy 59(9):p 1023-1024, September 2004
The most dramatic improvements Ive seen are in photoaged skin (sun damage), post-inflammatory hyperpigmentation, and overall skin resiliencethe kind of improvements that make you look healthier and more vital rather than just treated. Youre not going to reverse severe deep wrinkles or significant volume loss with GHK-Cu alone, but you will improve the quality of your skin tissue in ways that fillers and lasers cannot
(Springer, Cham: Springer Nature) 33745