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while potentially a low-energy diet could be deleterious for a variety of reasons, in wild-type mice energy restriction induced by a low energy diet has similar impacts on lifespan as energy restriction induced by many feeding small meals of a normal diet 54

The most common are pneumonia, abscesses of the skin, tissues, and organs, suppurative arthritis (invasion of the joints by infectious agent leading to generation of pus), and osteomyelitis (infection of the bone)

The reconstitution process adds another layer of risk

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[10] This is not a claim that GHK-Cu causes copper overload in healthy people