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These include: Severe rash or hives Shortness of breath Rapid heartbeat These side effects are significantly more serious and may require medical attention

Wang H, Li T, Sun F, Liu Z, Zhang D, Teng X et al (2022) Safety and efficacy of the SGLT2 inhibitor dapagliflozin in patients with systemic lupus erythematosus: a phase I/II trial

In addition, a portion of synthetic agents have been used clinically to treat various diseases, such as myocardial infarction, heart failure, diabetes, hypertension, tumors, and sepsis

Nathanson, S