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At least 76 drugs that target protein kinases have been approved for clinical use, and several kinase-targeted candidate therapeutics are in various stages of preclinical and clinical development for brain-related disorders [212]
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This sign results from multiple changes caused by periductal fibrosis, including dilated intrahepatic and extrahepatic ducts, straightened intrahepatic ducts with less acute angled branching, and decreased branching with acute tapering of the peripheral ducts
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