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The 12-month trial design enables us to assess senolytic-associated changes before and after treatment during the 3-month active treatment phase, track the reappearance of senescent cells after their removal during the 9-month post-treatment period, and evaluate disease trajectory differences over a one-year period (Figure 3)

Tesamorelin Commonly used to help reduce visceral fat and support metabolic health

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5.1 Short-chain fatty acids SCFAs, as final products of intestinal microbiota fermentation, might influence metabolic responses in numerous peripheral organs following absorption from the gut lumen (90)

More bioavailable forms like liposomal or reduced glutathione may work at lower doses