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3 Nicotine pharmacology and cardiovascular effects 3.1 Mechanisms of nicotine action As detailed by Benowitz (22) in his comprehensive review of nicotine pharmacology, nicotines addictive potential stems from its complex interaction with the nervous system, involving rapid central nervous system penetration and subsequent activation of neural reward pathways

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7 Tips for quitting smoking Nicotine is a highly addictive substance, making it challenging to quit smoking for good

Analytical biochemistry 72 , 248254 (1976)

It is important to exercise caution and be mindful of the potential effects of nicotine when smoking unfiltered cigars