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This synergy is the basis of the modified Kligman formula, a combination of hydroquinone, tretinoin and a mild corticosteroid that is approved by the FDA for hyperpigmentation

For one thing, the ageing process in humans is much slower than in rats, so the seven-week supplementation period used in the rat studies would equate to around five years of supplementation in humans

Only the simultaneous healing of the skin defect and the stomach defect would lead to the fistula closure (Skorjanec et al., 2009)