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Most patients notice only brief soreness at the injection site, and true allergic reactions are uncommon

Hypermethylation of the promoter region for the MTHFR gene silences it, further compromising transmethylation (Shaker et al., 2021)

Supplement alternatives to ALA If youre exploring options beyond alpha-lipoic acid for nerve health or oxidative stress, two of the most studied and promising alternatives are vitamin B12 and acetyl-L-carnitine (ALCAR).56 Each plays a unique role in nerve protection and repair, particularly in the context of diabetic neuropathy