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Epidemiological studies estimate that the global prevalence of overt hypothyroidism is approximately 4.6% in the United States and 5% in Europe, with even higher rates observed in iodine-deficient regions (Persani, 2012)

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Proteomics analysis Label-free LC-MS/MS was used for proteomics analysis of the blank group and D-CuP group (n = 3 in each group)

In a randomized controlled trial (RCT), Delia et al