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Monitoring requirements include assessment for signs of pancreatitis (persistent severe abdominal pain, often radiating to the back, with or without vomiting) and gallbladder disease (right upper quadrant pain, nausea, vomiting), both of which have been reported with GLP-1 receptor agonists

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4d) suggests significant changes in the expression of genes related to a range of metabolic signalling networks, including lipid, protein, nucleotide, carbon and reactive oxygen species metabolism